Clinical evaluation of two topical products containing blueberry extract, purple rice extract and pro-xylane in combination in Chinese female with mild-to-moderate facial aging

Zhenfeng Liu, Bin Yang, Fei Liu, Zhitao Liu

BACKGROUND

Facial aging is always a major problem in dermatology and aesthetic surgery. Blueberry extract and pro-xylane can inhibit the production of advanced glycation end products (AGEs) and promote the production of mucopolysaccharides. Purple rice extract can inhibit hyaluronic acid loss. Thus, a combination of two topical products containing blueberry, purple rice extract and pro-xylane may play a role in facial aging.

INTRODUCTION

Facial aging has caused serious troubles to patients’ lives，which is characterized by fine lines around the eyes, mouth, cheeks, skin laxity and lack of elasticity1. With aging, the number of advanced glycation end products (AGEs) increases, affecting every cell type in the body. The pathological effects of AGEs include increasing vascular permeability, inhibiting vasodilatation by interfering with nitric oxide, oxidizing LDL and inducing cytokine secretion2. All these factors increase oxidative stress and thus promote aging. Blueberry extract can inhibit the production of AGEs. Pro-xylane may mediate epidermal homeostasis3. These effects result in younger appearing skin, as the synthesis of GAGs increases the water binding capacity of the dermis and growth factors stimulate cell turnover.
Currently, no clinical research has been published on the use of blueberry extract, pro-xylane and purple rice extract in the Chinese population. Thus, our study aimed to evaluate the efficacy and satisfaction of two topical products containing blueberry extract, purple rice extract and pro-xylane (test product) for improving facial aging in Chinese subjects with mild-to-moderate facial aging.