Clinical evaluation of a new wrinkle correcting cream containing two flavonoid-rich fruit extracts

H. Pageon, S. Lynch, S. Anderias, H. Chaudhary, P. Brieva, X. Yan

INTRODUCTION

Both the dermal and epidermal function of chronogically aged skin can be impacted by the formation and accumulation of endogenous advanced glycation end products (AGEs). AGEs cause extracellular matrix (ECM) proteins to become brittle, weaken their reparative abilities, and degrade their overall integrity. The degradation of the ECM proteins manifests as signs of skin aging, sush as wrinkling and laxity. AGEs can also affect epidermal structural proteins like filaggrin and damage skin barrier function.

This research was designed to evaluate the anti-aging benefits of a new wrinkle correcting cream (flavonoid fruit extract cream) enriched with two flavonoid-containing blueberry and pomegranate fruit extratcts, known glycation inhibitors, in human clinical trials.
Three studies were carried out :

• A 12-week, double-blind, clinical study was conducted on 77 females to assess signs of skin aging
• A 24-hour, double-blind, clinical study was conducted on 29 subjects to measure skin hydration
• A 4-hour, double-blind, clinical study was conducted on 40 subjects to measure skin mechanical properties.