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A dermocosmetic regimen is beneficial in the management of skin sensitivity caused by a retinoid-based acne fixed combination
A. Khammari, D. Kerob, A.L. Demessant, G. Le Dantec, C. le Floc‘h, B. Dréno
- 10min
- Jul. 2023
- Supported by
INTRODUCTION
Acne vulgaris is a chronic inflammatory skin disease with a high prevalence during adolescence, and a growing incidence in adults.1-4 Its pathophysiology is multifactorial, with increased sebaceous glands and sebum production, hyperkeratinisation of the pilosebaceous infundibulum, skin microbiome disbalance and innate immunity activation.5 The herewith investigated dermocosmetic (DC) regimen consists of a cleanser and a cream formulation that has been developed to help to limit topical retinoid-induced skin discomfort in subjects with acne. The DC cream contains Bixa Orellana seed extract, a plant extract that reduces sebum production, hyperkeratinisation, and that reduces lipase activity from C. acnes. Moreover, the cream contains niacinamide, panthenol and the pre- and post-biotic Aqua Posae Filiformis (APF). The DC cleanser contains Bixa Orellana seed extract, niacinamide, mannose and APF.
The aim of this study was to assess the benefit of a DC regimen compared to a standardised skin care regimen including a cream and cleanser (RC) by reducing skin discomfort signs and symptoms induced by a retinoid/benzoyl peroxide fixed combination in acne subjects.