UV light produces DNA damage, photoaging and even carcinogenesis, through the formation of photoproduct and reactive oxygen species, activating DNA damage response (DDR) pathways and ultimately apoptosis or senescence. Telomeres are regions especially sensitive to UV light; their length shortens upon UV irradiation in-vitro and in-vivo, compromising the regenerative capacity and function of tissues. We aimed to study whether a broad-spectrum sunscreen product prevents UV-induced DNA damage and telomeric shortening.